Какао: влияние на факторы риска сердечно-сосудистых заболеваний. Обзор 36-ти мета-анализов и РКИ

1 The effects of whole foods and dietary patterns on flow-mediated dilation: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2025 Nov;122(5):1204-1232. doi: 10.1016/j.ajcnut.2025.09.020. Epub 2025 Sep 17. 2 Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis. J Agric Food Chem. 2025 Aug 6;73(31):19505-19517. doi: 10.1021/acs.jafc.5c05536. Epub 2025 Jul 26. 3 A meta-analysis on use of agro-industrial by-products rich in polyphenols in dairy small ruminant nutrition. Animal. 2025 Jul;19 Suppl 2:101522. doi: 10.1016/j.animal.2025.101522. Epub 2025 Apr 21. 4 Response of VO(2max) to dark chocolate consumption in healthy subjects: A systematic review and meta-analysis of randomized controlled trials. Physiol Rep. 2025 Mar;13(5):e70256. doi: 10.14814/phy2.70256. 5 Effect of dark chocolate/ cocoa consumption on oxidative stress and inflammation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of controlled trials. Complement Ther Med. 2024 Sep;84:103061. doi: 10.1016/j.ctim.2024.103061. Epub 2024 Jun 24. 6 Effects of Cocoa Consumption on Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials. Nutrients. 2024 Jun 18;16(12):1919. doi: 10.3390/nu16121919. 7 Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS. Am J Clin Nutr. 2024 Mar;119(3):692-701. doi: 10.1016/j.ajcnut.2023.12.011. Epub 2024 Jan 18. 8 Effects of Carob Extract on the Intestinal Microbiome and Glucose Metabolism: A Systematic Review and Meta-Analysis. Clin Ter. 2023 Nov-Dec;174(Suppl 2(6)):169-172. doi: 10.7417/CT.2023.2484. 9 Patterns of shade plant diversity in four agroforestry systems across Central America: a meta-analysis. Sci Rep. 2023 May 26;13(1):8538. doi: 10.1038/s41598-023-35578-7. PMID: 37237175 Free PMC article. 10 Dietary Flavonoids and Human Cognition: A Meta-Analysis. Mol Nutr Food Res. 2022 Nov;66(21):e2100976. doi: 10.1002/mnfr.202100976. Epub 2022 Apr 7. 11 Effect of Important Food Sources of Fructose-Containing Sugars on Inflammatory Biomarkers: A Systematic Review and Meta-Analysis of Controlled Feeding Trials. Nutrients. 2022 Sep 26;14(19):3986. doi: 10.3390/nu14193986. 12 Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis. Eur J Epidemiol. 2022 Apr;37(4):321-333. doi: 10.1007/s10654-022-00858-5. Epub 2022 Apr 23. 13 Conserv Biol. 2022 Feb;36(1):e13779. doi: 10.1111/cobi.13779. Epub 2021 Aug 27. 14 J Int Soc Sports Nutr. 2021 Dec 29;18(1):76. doi: 10.1186/s12970-021-00472-y. 15 Nutrients. 2021 Nov 26;13(12):4269. doi: 10.3390/nu13124269. 16 Chocolate and risk of chronic disease: a systematic review and dose-response meta-analysis. Eur J Nutr. 2020 Feb;59(1):389-397. doi: 10.1007/s00394-019-01914-9. Epub 2019 Feb 25. 17 Meta-analysis of Cognitive Performance Radiat Res. 2019 Nov;192(5):463-472. doi: 10.1667/RR15419.1. Epub 2019 Aug 15. 18 Braz J Otorhinolaryngol. 2018 May-Jun;84(3):381-388. doi: 10.1016/j.bjorl.2017.11.003. Epub 2017 Dec 24. 19 Public Health Nutr. 2018 Mar;21(4):766-776. doi: 10.1017/S1368980017003093. Epub 2017 Nov 16. 20 Cochrane Database Syst Rev. 2018 Feb 27;2(2):CD009315. doi: 10.1002/14651858.CD009315.pub2. 21 Nutrients. 2017 Dec 11;9(12):1345. doi: 10.3390/nu9121345. 22 Nutrients. 2017 Jul 2;9(7):688. doi: 10.3390/nu9070688. 23 Cochrane Database Syst Rev. 2017 Apr 25;4(4):CD008893. doi: 10.1002/14651858.CD008893.pub3. 24 Nutrients. 2017 Apr 20;9(4):402. doi: 10.3390/nu9040402. PMID: 28425931 Free PMC article. 25 Br J Clin Pharmacol. 2017 Jan;83(1):163-171. doi: 10.1111/bcp.12902. Epub 2016 Mar 15. 26 J Nutr. 2016 Nov;146(11):2325-2333. doi: 10.3945/jn.116.237644. Epub 2016 Sep 28. 27 Nutr Metab Cardiovasc Dis. 2016 Aug;26(8):722-34. doi: 10.1016/j.numecd.2016.01.003. Epub 2016 Jan 28. 28 Am J Clin Nutr. 2016 May;103(5):1344-56. doi: 10.3945/ajcn.115.119883. Epub 2016 Apr 13. 29 Heart. 2015 Aug;101(16):1279-87. doi: 10.1136/heartjnl-2014-307050. Epub 2015 Jun 15. 30 BMJ. 2012 Dec 6;345:e7666. doi: 10.1136/bmj.e7666. 31 Am J Clin Nutr. 2012 Mar;95(3):740-51. doi: 10.3945/ajcn.111.023457. Epub 2012 Feb 1. 32 J Nutr. 2011 Nov;141(11):1982-8. doi: 10.3945/jn.111.145482. Epub 2011 Sep 28. 33 BMJ. 2011 Aug 26;343:d4488. doi: 10.1136/bmj.d4488. 34 Am J Clin Nutr. 2010 Jul;92(1):218-25. doi: 10.3945/ajcn.2009.28202. Epub 2010 May 26. 35 BMC Med. 2010 Jun 28;8:39. doi: 10.1186/1741-7015-8-39. 36 Am J Clin Nutr. 2008 Jul;88(1):38-50. doi: 10.1093/ajcn/88.1.38.